Can the RTX 5080 16 GB run LTX-2.5 (22B)?
Download Q2_K (8.8 GB). With the model's working memory it needs about 13.6 GB, leaving 2.4 GB spare on 16 GB. Quality: heavy loss; a last resort. For better quality, Q3_K_M (11.5 GB) also runs, with about 0.3 GB spilling into system RAM — a little slower, still practical.
01What to download
| Part | File | Folder | Size | |
|---|---|---|---|---|
| Model | LTX-2.5-Distilled-Q2_K.gguf Q2_K · realrebelai/LTX-2.5_GGUFs | models/unet | 8.8 GB | Download → |
| Text encoder | gemma4-12b-with-proj-ltx-2.5-comfy-int8-convrot.safetensors Gemma 4 12B + LTX projection INT8 (convrot) · Lightricks/LTX-2.5 | models/text_encoders | 15.4 GB | Download → |
| VAE | ltx-2.5-video-vae-bf16.safetensors LTX-2.5 video VAE (DiffVAE) BF16 · Lightricks/LTX-2.5 | models/vae | 1.5 GB | Download → |
| Also needed | ltx-2.5-audio-vae-bf16.safetensors LTX-2.5 audio VAE + vocoder BF16 · Lightricks/LTX-2.5 | models/vae | 0.4 GB | Download → |
| Total download · keep about the same free on disk | 26.0 GB | |||
Alternatives: Gemma 4 12B + LTX projection BF16 (26.3 GB). The 16-bit text encoder is a little more faithful; the smaller one is chosen here because it loads faster and needs less RAM. Only for some workflows: LTX-2.5 latent spatial upscaler x2 (1.0 GB, official two-stage template); Gemma 4 E2B INT8 (prompt enhancer, optional) (5.2 GB, only if prompt enhancer enabled). Sizes read from Hugging Face (2026-09-25). “Download” links start the file directly; the file name links are the same files the official ComfyUI workflows use.
System RAM: 48 GB or more. ComfyUI keeps the model file, the text encoder and the VAE in system RAM and moves them to the GPU as needed. With this set of files that is about 26.0 GB, plus roughly 6 GB for Windows, ComfyUI and a browser: 32.0 GB in total. With less RAM it still runs, but Windows starts swapping to disk and loading gets very slow. calculated
02Every LTX-2.5 file on 16 GB
| File | Size | Needed | On this card | Quality | Download |
|---|---|---|---|---|---|
| 16-bit SAFETENSORS · Lightricks | 42.0 GB | 46.8 GB | 30.8 GB too big | the original weights | Hugging Face → |
| Q8_0 GGUF · realrebelai | 23.6 GB | 28.4 GB | 12.4 GB too big | practically identical to the original | Hugging Face → |
| Q6_K GGUF · realrebelai | 18.7 GB | 23.5 GB | 7.5 GB too big | very close to the original | Hugging Face → |
| Q5_K_M GGUF · realrebelai | 16.8 GB | 21.6 GB | 5.6 GB too big | close; small differences in fine detail | Hugging Face → |
| Q4_K_M GGUF · realrebelai | 15.1 GB | 19.9 GB | 3.9 GB too big | good; some loss in fine detail and text | Hugging Face → |
| Q3_K_M GGUF · realrebelai | 11.5 GB | 16.3 GB | spills 0.3 GB | noticeable loss of detail | Hugging Face → |
| Q2_K ← GGUF · realrebelai | 8.8 GB | 13.6 GB | fits · 2.4 GB spare | heavy loss; a last resort | Hugging Face → |
Sizes from the Hugging Face file listing, read 2026-09-25. “Needed” = file + 4 GB working memory for this model + 0.8 GB kept free for the system.
03The text encoder
Gemma 4 12B (custom LTX-2.5 build): 26.3 GB as 16-bit, 15.4 GB as INT8. ComfyUI encodes the prompt first and can push the encoder out of VRAM before sampling, so it does not have to fit together with the model. On 16 GB the encoder itself is too big for VRAM, so let it run from system RAM: slower prompt encoding, same images.
04About this GPU
The RTX 5080 16 GB is a Blackwell GPU with FP8 and FP4 hardware: ComfyUI computes Comfy-Org's FP8 files natively here, and NVFP4 files (where a model offers them) are faster still.
RTX 5080 16 GB: 16 GB GDDR7 · 256-bit · 960 GB/s · Blackwell. Everything that runs on the RTX 5080 16 GB →
05What more VRAM would change
With 32 GB you could run LTX-2.5 at 8-bit or better (Q8_0, 23.6 GB) with no offloading: for example on the RTX 5090 32 GB.
What changes from the RTX 5080 16 GB to the RTX 5090 32 GB →
06Measured and reported results
Nobody has sent measured numbers for this pair yet. If you run LTX-2.5 on a RTX 5080 16 GB, send your time per image and peak VRAM and it will appear here, credited.
07Questions
How much VRAM does LTX-2.5 need?
Around 13.6 GB with the smallest file (Q2_K) and 28.4 GB with an 8-bit file (Q8_0), counting working memory and a small system reserve. The full 16-bit file needs about 46.8 GB.
Which LTX-2.5 file should I download for the RTX 5080 16 GB?
Q2_K (8.8 GB) from realrebelai/LTX-2.5_GGUFs. Load it with Unet Loader (GGUF) from the ComfyUI-GGUF node pack.
Is FP8 faster than GGUF on the RTX 5080 16 GB?
It can be. This GPU has FP8 hardware, and ComfyUI computes FP8 natively for files made for it (Comfy-Org's fp8_scaled files), or for any FP8 file with the --fast fp8_matrix_mult option. GGUF files are unpacked on the fly, which costs some speed.
How much do I need to download for LTX-2.5 on the RTX 5080 16 GB?
About 26.0 GB for the model file, text encoder and VAE listed on this page, and the same again free on disk. With a 16 GB card, 48 GB of system RAM or more is recommended.